Clinical Psychology 9 (2016), 1, 97-97

Oral papers

Could Testosterone Undecanoate in Hypogonadal Patients Improve Anemia, Inflammation, and Cardiovascular Risk Factor? An Observational, 54-Week Cummulative Registrry Study

J. Park - Chonbuk National University Hospital, Jeonju, South Korea
S. Lee - Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea
S. Yang - Konkuk Uinversity School of Medicine, Chungju, South Korea
J. Kim - Chonbuk National University Hospital, Jeonju, South Korea
Y. Shin - Chonbuk National University Hospital, Jeonju, South Korea

Fulltext (english, pages 97-97).pdf

Objective: The aim of this study was to investigate if testosterone undecanoate in patients with hypogonadism attenuates anemia and the risk for cardiovascular disease. Design and Method: A registry study consisted of 58 participants with subnormal total testosterone level (<2.35 ng/ml) and at least mild symptoms of testosterone deficiency. All the patients were injected with 1,000 mg of testosterone undecanoate on initial visit, followed by injection at 6, 18, 30, 42 and 54 weeks. Serum hormones, Hb, Hct, anemia and inflammation relating factors, lipid profiles, whole blood viscosity and anthropometry were measured. Results: Total testosterone (from 1.87 ± 1.09 to 5.52 ± 1.92 ng/ml, p <0.001) and free testosterone (p <0.001) were restored by testosterone undecanoate therapy. Hb and Hct significantly increased after testosterone undecanoate therapy by an average of 2.46 g/dl (p <0.001) and 3.03% (p <0.001), respectively. Prevalence of anemia (from 29.6 to 10.0%) and total cholesterol (p = 0.002), hs-CRP (p <0.001), ESR (p <0.001) significantly decreased (p <0.001) and patients with anemia showed a significant increase in erythropoietin (p = 0.047) after testosterone undecanoate therapy. Higher whole blood viscosity and increased Hct were observed until 54 weeks compared with baseline, however whole blood viscosity and Hct stabilized after 18 weeks. Conclusions: 54-week testosterone undecanoate decreased the prevalence of anemia and components of metabolic syndrome. A longer duration testosterone undecanoate therapy of more than 18 weeks may be effective and safe in reducing the blood viscosity and improving anemia in the patients with hypogonadism

© Naklada Slap, with you since 1985. All rights reserved.
Kontakt: Head office

Dr. Franje Tuđmana 33, 10450 Jastrebarsko

+ 385 (0)1 6281 774
Branch office

Centar za edukacije i istraživanja
Miramarska cesta 105, 10000 Zagreb
+ 385 (0)1 6313 044