Original scientific paper
Cognitive profile in recent-onset
schizophrenia
Krunoslav Matešić
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Department of Psychology, Catholic University of Croatia, Zagreb, Croatia
Vjekoslav Peitl
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School of Medicine, Catholic University of Croatia, Zagreb, Croatia
Dalibor Karlović
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Department of Psychiatry, University Hospital Centre Sestre milosrdnice, Zagreb, Croatia
https://doi.org/10.21465/2025-KP-1-2-0002
Fulltext (english, pages 21-32).pdf
Abstracts
The aim of this study was to compare WAIS‑IV and WMS‑IV performance in recent‑onset schizophrenia
(ROS) with performance in a demographically matched healthy comparison group. Forty‑three ROS
inpatients were compared with 43 healthy individuals drawn from the Croatian standardization samples for
the WAIS‑IV and WMS‑IV and matched to patients on age, sex and years of education. Primary analyses used
separate MANCOVAs (Pillai’s Trace) on WAIS‑IV and WMS‑IV index scores with Group as the between‑subjects
factor and years of education as a covariate. Significant multivariate effects were followed by univariate
ANCOVAs on each index, with Holm correction across the nine index tests. Clinical interpretability was
summarized by the proportion of participants falling below −1 SD and −1.5 SD relative to the control‑group
distribution. Large deficits were observed on WAIS‑IV Processing Speed and Working Memory, with sizable
effects on Perceptual Reasoning and Verbal Comprehension. WMS‑IV showed very large decrements in Immediate
and Delayed Memory and large reductions in Visual Memory and Visual Working Memory. These
findings suggest that broad cognitive impairment is already evident near illness onset, with slowed processing
and episodic‑memory dysfunction being prominent targets for early assessment and remediation.
Keywords
schizophrenia, cognition, WAIS‑IV, WMS‑IV, processing speed, episodic memory