Objective: In Iran, sexual understandings are strongly determined by religious teaching among women in particular. The aim of this study was to determine the role of religion on Iranian women’s sexual practice evolution. our purpose was to detect women’s individual conceptualization of Islamic Shiite principles and their practice upon these conceptualizations. Design and Method: In this qualitative study, 52 married women in their reproductive age were interviewed (n=4) and participated in eight focus group discussions. They were selected from public health centers in Rafsanjan. Emerged data from the interviews and focus group discussions were analyzed using content analysis. Results: Findings are categorized in three major themes: “unconditional obedience”, ”inconsistency between obedience and virtue”, “misunderstandings”. Conclusions: Religious teaching has a basic and comprehensive role in sexual behavior construction and sexual health of women. However, occasional inconsistency between believes, learning and sexual expectations, practices and situations would lead to jeopardize the psychological and somatic health of women. Misunderstandings have essential role in making such problems.