Objective: Pregnancy is a very special time in women’s life, because it is a period that involves a lot of biological, psychological and relationship changes with their partners. It is in this context of changes that sexuality can be profoundly affected. This research investigates these changes in women sexuality during pregnancy. Design and Method: This is a qualitative and descriptive research that used the study of clinical cases. For this research, there was a group of married women that joined the program. The women were between 25 and 40 years old and got pregnant in the years 2014 and 2015. Results: The results indicate that the main changes in sexuality were: decreased sex drive, insecurities with physical appearance and attractiveness, partner’s jealousy, lack of affection, absence or reduction in the frequency of intercourse, pain during sexual intercourse, fear of not being desired by the spouse, difficulties in reconciling the roles of mother and wife, afraid that the penetration hurts the baby, anxiety about childbirth and concerns with the ideal of being a good mother. Conclusions: Pregnant women experience significant changes in sexuality during pregnancy. These changes can be mitigated with psychological care support, where women may reflect on their fears and anxieties, and to strengthen their selfconfidence and self-esteem. The participation of the partner in this period is crucial, including psychological counseling for the couple. Although it is a time of strong emotions, pregnancy may foster sexual experience and increase the complicity of the partners.