Objective: Past research has indicated that sexual abuse is related to mental and physical health conditions and that mental and physical health conditions are related to decreased health-related quality of life (HRQOL). However, little is known about the relationship between sexual abuse and HRQOL. The purpose of the present study is to investigate whether early sexual abuse is an important predictor of adult HRQOL in the current analysis. Design and Method: We recruited 267 subjects from 2009 September to 2015 December by advertisement in Korea. We excluded pregnancy, seizure, major psychiatric and medical illness patients such as schizophrenia, mood disorder, anxiety disorder, severe hypertension and diabetes. We measured the Early Trauma Inventory for sexual abuse, coping scale and sociodemographic. IBM SPSS version 21.0 was used for statistical analysis. Results: Multiple linear regression analyses showed that HRQOL physical functioning (PF) subscale can be related to early sexual abuse after adjusting age, gender, education, problem solving coping style which were significantly correlated with HRQOL PF subscale. Conclusions: This study suggested that early sexual abuse is an important determinant of HRQOL PF in general population.