Objective: The objective of this study was to explore the framework between attitude toward sexual health care (SHC) and intention of on providing PLISSIT model of SHC of practice nurses in Taiwan. Design and Method: This is a cross-sectional descriptive research, using the Nursing Attitude on SHC scale (NASHC) and intention of Nursing Intervention on SHC (NISHC) to assess attitude and behavioral intention toward SHC. This study was conducted with 168 practice nurses in Taiwan. Data were collected between November 2012 and April 2013. The research model was evaluated through structural equation modeling (SEM). Results: We found that individuals with a high score on attitude toward SHC were more likely to behave in ways that would provide SHC. All of the loadings on the latent variables were statistically significant, the contribution of each subscale was in range 51-85%. After confirmatory factor analysis, the measurement model provided an adequate fit with the data, with AGFI = 0.92, GFI = 0.96, CFI = 0.92, SRMR = 0.05 and RMSEA = 0.057. Conclusions: The results are consistent with the priori hypothesized model of behavioral intention of SHC. Practice nurses’ attitude is varied toward hierarchy levels of permission/limited information/specific suggestions/intensive (PLISSIT) model of SHC. The research suggests that addressing attitude towards SHC needs to be a priority to promote practice nurse providing SHC in clinical practice.