Klinička psihologija

Clinical Psychology 9 (2016), 1, 126-126

Poster display

KH-204 Protects Oxdidative Stress-Induced Testicular Apoptosis by Erk and Akt Pathways

W. Bae - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
J. B. Choi - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
K. S. Kim - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
S. J. Kim - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
H. J. Cho - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
U. S. Ha - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
S. H. Hong - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
J. Y. Lee - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea
S. W. Kim - Department of Urology, Seoul St. Mary’s Hospital, Seoul, South Korea

https://doi.org/10.21465/2016-KP-P-0008

Fulltext (english, pages 126-126).pdf

Abstracts

Objective: Korean herbal formulation, Ojayeonjonghwan is used to treat lateonset hypogonadism (LOH) symptoms including erectile dysfunction (ED). Previous study demonstrated that the modified Ojayeonjonghwan (KH-204) can be developed as a therapeutic alternative medicine to improve ED. We examined the pharmacological effects of KH-204 in vitro and in a LHRH agonist-induced LOH rat model. Design and Method: TM3 Leydig cell viability was measured based on oxidative stress according to the treatment. We investigated either distilled water (shamoperated) or leuprorelin 0.5mg/kg, which was subcutaneously administered once to the back of rats. Male rats were divided into four groups (n = 8 in each): a normalcontrol group, an androgen-deprived control group and two androgen-deprived groups treated p.o. with either 200 or 400 mg/kg, KH-204 for 4 weeks. The testes and epididymides from rats in all groups were removed, weighed and subjected to histological examination after treatment. Results: KH-204 protected TM3 cells from oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in androgen-deprived or aging male rats were significantly enhanced, and germ cell apoptosis was reduced after treatment. Conclusions: These results suggested that KH-204 may alleviate the oxidative 0stress via ERK and Akt pathways, and it may contribute to the improvement of serum testosterone levels

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